Knowledge and Data Management White Papers
Alternative Splicing Analysis of Data From Affymetrix Exon Arrays Using JMP Genomics
Overview Analysis of alternative splicing in expressed genes is of growing interest to researchers. While powerful, the standard 3'-biased expression microarrays do not provide a full picture of the molecular events that may be involved in disease. Apparent increases or decreases in summarized transcript levels may be due to alternative exon splicing or, conversely, differences in transcript levels due to alternative splicing may not even be detectable in a 3'-biased assay. To detect exon-level changes, samples must be hybridized to arrays with more complete coverage of exons, like the Affymetrix whole transcript and exon arrays. Tiling arrays, sequencing within selected genomic regions, or whole genome sequencing may also be used to generate data sets for analysis of alternative splicing patterns.
| Publisher | SAS Institute | File Format | |
|---|---|---|---|
| Date Published | April 2009 | ||
| Format | White Papers | ||
| Topics | |||
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