Database Management White Papers
Nucleotide Substitutions and the Evolution of Duplicate Genes
Overview The article tells about the performance of a series of computational experiments designed to shed light on the origin and subsequent evolution of duplicate genes. For these experiments it constructed databases with the complete set of available coding sequences for nine different species. A heuristic similarity search program compared each sequence to every other sequence from the same genome to locate potential duplicates. This paper describes the software developed for these experiments. The input to the program is a stream of aligned amino acid sequences, and the output is a set of aligned nucleotide sequences with codons placed according to the amino acid alignment. It then describes how the nucleotide sequences can be processed to estimate the accumulation of nucleotide substitutions. It concludes by summarizing some of the results of the experiments.
| Publisher | Stanford Knowledgebase | File Format | PDF, requires Acrobat Rdr 5 |
|---|---|---|---|
| Date Published | June 2001 | Downloads | 28 |
| Format | White Papers | ||
| Topics | |||
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