Genetic Engineering White Papers
Application of Nuclear Transfer Technology in the Generation of Donor Pigs for Xenetransplantation
Overview
The critical shortage of human organs available for transplantation in the treatment of end-stage organ disease has greatly accelerated research and development in the field of xenotransplantation. A combination of physiological, biological, economic and ethical considerations make the pig the most likely animal for sustainable use as a xenogeneic organ donor.
Suppression of cell-mediated rejection mechanisms is currently accomplished in human allograft transplantation with drug therapy. Transplantation of pig organs into humans requires elimination or suppression of hyperacute and acute vascular rejection mechanisms particular to xenografts, as well as means to modulate a more vigorous cellular response. Modifications of the pig genome, through functional deletion of pig genes and introduction of human genes, have been proposed to deal with the various immunological barriers. Dominant modification of the genome has already been undertaken, with some promising results in terms of extended organ survival in primate animal models.
| Publisher | National Institute of Standards and Technology | File Format | HTML |
|---|---|---|---|
| Date Published | August 2003 | Downloads | 8 |
| Format | White Papers | ||
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